5330-29-0

Name	N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine dihydrochloride
CAS	5330-29-0
EINECS(EC#)	226-224-0
Molecular Formula	C21H34ClN3O
Molecular Weight	379.97
MOL File	5330-29-0.mol

Synonyms

WR-006026 N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine dihydrochloride 1,6-Hexanediamine,N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-, hydrochloride (1:2)

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Chemical Properties

Melting point

179-180°

Hazard Information

Uses

Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1][2].

References

[1] López-Martín C, et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob Agents Chemother. 2008;52(11):4030-4036. DOI:10.1128/AAC.00964-08
[2] Luis Carvalho, et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother. 2011 Sep;55(9):4204-10. DOI:10.1128/AAC.00520-11

Supplier

Shaanxi Dideu Newmaterial Co., Ltd.

Telephone029-63373950 17392216152

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1184346/0_EN.htm

TargetMol

Telephone400-821-0310 15002144251

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