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(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors[1]. And (E)-Dehydrodiconiferyl alcohol suppresses the NF-κB nuclear translocation in connective tissue of healing area[2].

ChEBI: Dehydrodiconiferyl alcohol is a guaiacyl lignin obtained by cyclodimerisation of coniferol. It has a role as a plant metabolite and an anti-inflammatory agent. It is a member of 1-benzofurans, a primary alcohol, a guaiacyl lignin and a member of guaiacols. It is functionally related to a coniferol.

[1] Costa G, et al. In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with IX and XII?hCA Inhibition.?Antioxidants (Basel). 2020;9(9):775. Published 2020 Aug 21. DOI:10.3390/antiox9090775
[2] Hu X, et al. Dehydrodiconiferyl alcohol from Silybum marianum (L.) Gaertn accelerates wound healing via inactivating NF-κB pathways in macrophages.?J Pharm Pharmacol. 2020;72(2):305-317. DOI:10.1111/jphp.13205