Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits[1].
Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2].
Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3].
| Animal Model: | Dogs with cardiac arrhythmias[2] |
| Dosage: | 30-60 μg/kg |
| Administration: | Administered by the fourth ventricle |
| Result: | Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia.
Converted arrhythmias to sinus rhythms.
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