522649-59-8

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent malic enzyme (ME1) inhibitor with IC50 of 0.15 μM.

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[1] Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. DOI:10.1016/j.bmcl.2005.10.065
[2] Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. DOI:10.1038/s41598-018-32532-w