520-52-5

Crystallin Solid

The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. Psychomimetic. Controlled substance (hallucinogen).

The intentional ingestion of hallucinogenic mushrooms by Mesoamerican natives dates back centuries. Early European explorers documented the Mayan and Aztec symbolism depicting the use of mushroom during spiritual ceremonies. Albert Hofmann first synthesized lysergic acid diethylamide (LSD) from psilocybin extracted from mushrooms. During the 1960s and 1970s, researchers conducted experiments on the utility of psilocybin for psychotherapy before drug laws curbed its use. Psilocybin is described as an entheogen, a substance used to raise spiritual consciousness. Today most countries have outlawed psilocybin possession; however, widespread illicit use continues.

[1] NICHOLS D. Improvements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin[J]. Synthesis-Stuttgart, 1999, 10 1: 935-938. DOI: 10.1055/s-1999-3490
[2] GRANT C. GLATFELTER*, MICHAEL H. BAUMANN   Structure–Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice[J]. ACS Pharmacology and Translational Science, 2022, 5 11: 1181-1196. DOI: 10.1021/acsptsci.2c00177
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