ChemicalBook CAS DataBase List 51753-57-2

51753-57-2

Name	7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one
CAS	51753-57-2
EINECS(EC#)	682-231-2
Molecular Formula	C15H10BrClN2O
MDL Number	MFCD00423674
Molecular Weight	349.61
MOL File	51753-57-2.mol

Synonyms

2H-1,4-BENZODIAZEPIN-2-ONE, 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO- 5-(2-Chlorophenyl)-7-bromo-1,4-benzodiazepin-2-one 7-BROMO-5-(2-CHLORO-PHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 7-BROMO-5-[O-CHLOROPHENYL]-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE IFLAB-BB F0133-0017 PHENAZEPAM 1,3-dihydro-7-bromo-5-(2-chlorophenyl)-2h-4-benzodiazepin-2-one 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one bd98 fenazepam 7-BROMO-5-(2-CHLORO-PHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE(PHENAZEPAM) PHENAZEPAM [7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE] 7-Bromo-5-(2-Chlorophenyl)-1,3-Dihydro-3H-1,4-Benzodiazopine-2-One 7-Chloro-5-(2-fluoro-phenyl)-1 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-3H-1,4-benzodiazepin-2-one Phenazapam 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, 99+% 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzdiazepin-2-one 5-(2-Chlorophenyl)-7-bromo-1,3-dihydro-3H-1,4-benzodiazepin-2-one 5-(2-Chlorophenyl)-7-bromo-1H-1,4-benzodiazepine-2(3H)-one

Chemical Properties

Melting point	214-224°C
Boiling point	493.0±45.0 °C(Predicted)
density	1.61±0.1 g/cm3(Predicted)
Fp	2℃
storage temp.	Controlled Substance, -20°C Freezer
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	11.58±0.70(Predicted)
color	Pale Yellow
Usage	A benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety
Major Application	clinical testing
InChI	1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey	CGMJQQJSWIRRRL-UHFFFAOYSA-N
SMILES	Clc1ccccc1C2=NCC(=O)Nc3ccc(Br)cc23
CAS DataBase Reference	51753-57-2(CAS DataBase Reference)

Safety Data

Hazard Codes	F,Xn
Risk Statements	11-20/21/22-36 less more
Safety Statements	16-36/37 less more
RIDADR	UN 1648 3 / PGII
WGK Germany	2
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 Muta. 1B
Toxicity	LD50 ipr-rat: 720 mg/kg KHFZAN 13(10),108,79 less more

Hazard Information

Description

Phenazepam (CRM) (Item No. ISO60172) is a certified reference material categorized as a benzodiazepine. It has sedative and hypnotic properties and has been detected in illicit tablets. This product is intended for research and forensic applications.

Chemical Properties

7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is Pale Yellow Solid

Uses

7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety

General Description

Phenazepam, a benzodiazepine drug produced in Russia, is used in Europe as an anxiolytic, anticonvulsant, and muscle relaxant. Although not used therapeutically in the US, the drug can be purchased on the internet for “laboratory research” purposes. Cases of abuse have been reported from European countries such as Sweden and Russia to states including New York, Kentucky, North Carolina, and Georgia.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí, Brí, and NOx.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] OYEMADE A. New uncontrolled benzodiazepine, phenazepam, emerging drug of abuse.[J]. Innovations in clinical neuroscience, 2012, 9 9: 10.

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