51330-27-9

Name	SOYASAPONIN I
CAS	51330-27-9
Molecular Formula	C48H78O18
MDL Number	MFCD02752366
Molecular Weight	943.12
MOL File	51330-27-9.mol

Chemical Properties

Melting point	220-222 °C(Solv: methanol (67-56-1))
Boiling point	1024.2±65.0 °C(Predicted)
density	1.41
storage temp.	2-8°C
solubility	ethanol: soluble1mg/mL, clear, colorless
pka	2.76±0.70(Predicted)
InChIKey	PTDAHAWQAGSZDD-IOVCITQVSA-N

Safety Data

WGK Germany	3
HS Code	29389090

Hazard Information

Description

Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities. It selectively inhibits human recombinant and porcine kidney renin (IC₅₀s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 μg/ml. Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (K_i = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 μM. It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress. Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid (Item No. 14584).
Uses
Soyasaponin I has been used:
- to test its effect on migration and invasion of ovarian cancer cell lines
- as standard for the quantification of saponins from quinoa and fenugreek samples
- as L-15 medium supplement for Zebrafish liver cell lines
General Description

Soyasaponin I is an oleanene-type triterpenoid aglycone and is a group B soyasaponin. It is an amphiphilic molecule and is metabolized by intestinal bacteria into sugars and aglycones.
Biochem/physiol Actions

Antioxidant and anti-inflammatory saponin found in soybean. Attenuates TNBS-induced colitis in mice. The structure consists of a glycoside moiety and triterpene derivative. Sialytransferase inhibitor and renin inhibitor.

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Shanghai Tauto Biotech Co., Ltd.

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Chembest Research Laboratories Limited

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Chengdu XiYa Chemical Technology Co., Ltd.

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Chengdu Biopurify Phytochemicals Ltd.

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Chengdu Climax Biotech Co., Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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Cheng Du Micxy Chemical Co.,Ltd

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Shanghai Ruji Biology Technology Co., Ltd.

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Shanghai BeiZhuo Biotech Co., Ltd.

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Shanghai JONLN Reagent Co., Ltd.

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Huainan Kedi Chemical Factory

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Websitehttp://www.weikeqi-biotech.com

Chengdu HuaXia Chemical Reagent Co. Ltd

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Websitehttp://www.reading-chemicals.com
Shanghai Aspire Biological Technology Co., Ltd.

Telephone021-61317773

Websitehttp://www.aspirebio.com

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51330-27-9

Hazard Information

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General Description

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