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Denotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy[1].

[1] Machoń Z, et al., Immunotropic activity of vratizolin (ITCL, Denotivir). Pol J Pharmacol. 2001 Jul-Aug;53(4):377-83. PMID:11990084