ChemicalBook CAS DataBase List 511-26-2

511-26-2

Name	1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
CAS	511-26-2
Molecular Formula	C22H34O2
MDL Number	MFCD00046237
Molecular Weight	330.5
MOL File	511-26-2.mol

Chemical Properties

Melting point	123.5°
alpha	D18 +18° (c = 1.085 in chloroform)
Boiling point	426.6±45.0 °C(Predicted)
density	1.04±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 25 mg/mL (75.64 mM)
form	Solid
color	White to off-white

Hazard Information

Uses

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2].

Biological Activity

MAP4343 is a 3-methyl ether derivative of Pregnenolone. It binds to microtubule-associated protein 2 (MAP2) in vitro, stimulates the polymerization of tubulin, enhances neurite extension and protects neurons from neurotoxic agents.

in vitro

MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro. It stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.

in vivo

MAP4343 (12 mg/kg; daily sc for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.

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Animal Model:	Adult Sprague-Dawley male rats with spinal cord injury
Dosage:	12 mg/kg
Administration:	Daily sc for 28 days
Result:	Increased the number of animals able to walk with weight-supported plantar steps. Showed forelimb-hindlimb coordination at the end of the study.

storage

Store at -20°C

References

[1] Fontaine-Lenoir V, et, al. Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4711-6. DOI:10.1073/pnas.0600113103
[2] Duchossoy Y, et, al. Treatment of experimental spinal cord injury with 3β-methoxy-pregnenolone. Brain Res. 2011 Jul 27;1403:57-66. DOI:10.1016/j.brainres.2011.05.065

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