ChemicalBook CAS DataBase List 51-57-0

51-57-0

Name	(+)METHAMPHETAMINE HYDROCHLORIDE
CAS	51-57-0
EINECS(EC#)	200-106-9
Molecular Formula	C10H16ClN
MDL Number	MFCD00056130
Molecular Weight	185.69
MOL File	51-57-0.mol

Chemical Properties

Melting point	166-168?C
alpha	D25 +14 to +20°
Fp	9°C
storage temp.	Controlled Substance, -20°C Freezer
EPA Substance Registry System	Methamphetamine hydrochloride (51-57-0)

Safety Data

Hazard Codes	T,F
Risk Statements	25-39/23/24/25-23/24/25-11 less more
Safety Statements	45-36/37-16 less more
RIDADR	3249
WGK Germany	2
RTECS	SH5455000
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
HS Code	2939710000
Safety Profile	Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of NOx and HCl. See also BENZEDRINE and various amphetamines. less more
Toxicity	LD50 i.p. in mice: 70 mg/kg (Lands) less more

Hazard Information

Chemical Properties

Off-White Solid

Uses

A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant).

Definition

ChEBI: A hydrochloride having methamphetamine as the base component.

Description

(+)-Methamphetamine (Item No. 13997) is an analytical reference material categorized as an amphetamine. It is the more physiologically active isomer of (±)-methamphetamine and is both neurotoxic and frequently abused. Methamphetamine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Originator

Desoxyn ,Abbott Laboratories

Manufacturing Process

2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was treated by eqimolar quantity of hydrochloric acid.

Therapeutic Function

Sympathomimetic, Central stimulant

General Description

Methamphetamine, (+)-1-phenyl-2-methylaminopropanehydrochloride desoxyephedrine hydrochloride (Desoxyn), isthe N-methyl analog of dextroamphetamine. It has moremarked central and less peripheral action than dextroamphetamine.It has a very high abuse potential, and by the intravenousroute, its salts are known as “speed.” The overallabuse problem presented by the drug is a national disaster.Medicinally acceptable uses of methamphetamine are analogousto those of dextroamphetamine.

Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

References

[1] DAVID JIROVSKY . Methamphetamine — properties and analytical methods of enantiomer determination[J]. Forensic science international, 1998, 96 1: Pages 61-70. DOI: 10.1016/s0379-0738(98)00104-2
[2] SHAOBIN YU. Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology.[J]. Behavioural Neurology, 2015, 2015: 103969. DOI: 10.1155/2015/103969
[3] RICHARD B ROTHMAN. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 307 1: 138-145. DOI: 10.1124/jpet.103.053975
[4] JUSTIN K ICHIDA. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.[J]. Cell stem cell, 2009, 5 5: 491-503. DOI: 10.1016/j.stem.2009.09.012

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