ChemicalBook CAS DataBase List 5051-62-7

5051-62-7

Name	GUANABENZ
CAS	5051-62-7
EINECS(EC#)	225-750-8
Molecular Formula	C8H8Cl2N4
MDL Number	MFCD00027408
Molecular Weight	231.08
MOL File	5051-62-7.mol

Chemical Properties

Melting point	227-229° (dec)
Boiling point	353.9±52.0 °C(Predicted)
density	1.49±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM)
pka	pKa 8.1 (Uncertain)
Water Solubility	Water: Insoluble

Safety Data

Hazard Codes	Xn
Risk Statements	20/21/22-62 less more
Safety Statements	22-36/37/39 less more
RIDADR	3249
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III

Hazard Information

Description

Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.

Originator

Wytensin,Wyeth,US,1982

Uses

alpha agonists

Uses

It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.

Definition

ChEBI: Guanabenz is a dichlorobenzene.

Manufacturing Process

A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off; MP 225°C to 227°C.

Therapeutic Function

Antihypertensive

Synthesis

Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine.

Synthesis_5051-62-7

storage

Store at -20°C

Purification Methods

Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.]

Spectrum Detail

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