ChemicalBook CAS DataBase List 5051-62-7

5051-62-7

Name	GUANABENZ
CAS	5051-62-7
EINECS(EC#)	225-750-8
Molecular Formula	C8H8Cl2N4
MDL Number	MFCD00027408
Molecular Weight	231.08
MOL File	5051-62-7.mol

Chemical Properties

Melting point	227-229° (dec)
Boiling point	353.9±52.0 °C(Predicted)
density	1.49±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM)
pka	pKa 8.1 (Uncertain)
Water Solubility	Water: Insoluble

Safety Data

Hazard Codes	Xn
Risk Statements	20/21/22-62 less more
Safety Statements	22-36/37/39 less more
RIDADR	3249
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III

Hazard Information

Description

Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.

Originator

Wytensin,Wyeth,US,1982

Uses

alpha agonists

Uses

It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.

Definition

ChEBI: Guanabenz is a dichlorobenzene.

Manufacturing Process

A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off; MP 225°C to 227°C.

Therapeutic Function

Antihypertensive

Synthesis

Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine.

Synthesis_5051-62-7

storage

Store at -20°C

Purification Methods

Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.]

Spectrum Detail

Supplier

Guangdong Qianjin Chemical Reagent Co., Ltd.

Telephone0751-2818792 13435114148

Websitehttp://www.gdqianjinchem.com/

Hangzhou Sage Chemical Co., Ltd.

Telephone+86057186818502 13588463833

Websitehttp://www.sagechem.com/

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai TaoSu Biochemical Technology Co., Ltd.

Telephone021-33632979

Websitehttp://www.tsbiochem.com

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185

Websitehttp://www.caerulumpharma.com

Finetech Industry Limited

Telephone027-87465837 19945049750

Websitehttps://www.finetechchem.com/

Shanghai HuanChuan Industry Co.,Ltd.

Telephone021-61478794

Websitehttp://www.hcshhai.com

Shanghai JiYi Biotechnology Co. Ltd.

Telephone 13621943973

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16460/0.htm

ShangHai Biochempartner Co.,Ltd

Telephone177-54423994 17754423994

Websitehttps://www.biochempartner.com

Shanghai Chaolan Chemical Technology Center

Telephone021-QQ：65489617 15618227136

Websitehttp://www.atkchemical.com/

Amadis Chemical Company Limited

Telephone571-89925085

Websitehttp://www.amadischem.com

Finetech Industry Limited

Telephone+86-27-87465837 +8618971612321

Websitehttps://www.finetechnology-ind.com/

Dideu Industries Group Limited

Telephone+86-29-89586680 +86-15129568250

Websitehttps://www.dideu.com

AFINE CHEMICALS LIMITED

Telephone+86-0571-85134551

Websitehttp://www.afinechem.com/index.html

Career Henan Chemica Co

Telephone+86-0371-86658258 +8613203830695

Websitehttps://www.coreychem.com/

DC Chemicals

Telephone021-58447131 13564518121

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm

Jingmo (Xiamen) Biotechnology Co., Ltd

Telephone 13621943973

Websitehttp://www.jamxmpharmatech.com/

Shanghai Luofa Biochemical Technology Co., Ltd.

Telephone021-51111890 15317326293

Websitehttps://www.molnova.cn/

1of4

Send Inquriy