Description
Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC
50 = 39.6 μM).
1 It is schistosomicidal, killing 100% of adult
S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM.
2 It has been used as a starting material for the synthesis of mono- and
bis-benzoxazines.
3
Uses
2-Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50=39.6 μM). 2-Methylcardol triene is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM. 2-Methylcardol triene has been used as a starting material for the synthesis of mono- and bis-benzoxazines.
References
1. Toyomizu, M., Sugiyama, S., Jin, R.L., et al. α-Glucosidase and aldoser reductase inhibitors: Constituents of cashew, anacardium occidentale, nut shell liquids Phytother. Res. 7,252-254(1993).
2. Attanasi, O.A., Behalo, M.S., Favi, G., et al. Solvent free synthesis of novel mono- and bis-benzoxazines from cashew nut shell liquid components Curr. Org. Chem. 16(21),2613-2621(2012).
