ChemicalBook CAS DataBase List 502496-16-4

502496-16-4

Name	Urtoxazumab
CAS	502496-16-4

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Animal Model:	5-week-old male DBA/2J mice, STEC B2F1-infection model^[1]
Dosage:	0.25, 0.5, 1.0, 2.0 and 2.5 mg/kg
Administration:	Intravenous administration, 1 h before and 12, 24, and 48 h after infection
Result:	Pretreatment completely protected the infected mice from death, the efficacy of the low dose (0.25 mg/kg) was partial when administered at 12 and 24 h after infection, but the efficacy of the high dose (2.5 mg/kg) was still complete. Prevented death from B2F1 infection in all 20 animals at 1.0 and 2.0 mg/kg 24 h after infection.