496-12-8

Isoindoline can be considered as the “hydrogenated sister” of isoindole which is widespread in nature as heterocyclic core of alkaloids and antibiotics.

Isoindoline is a white to off-white solid at room temperature and pressure, poor solubility in water, it has a certain basicity, and can be nucleophilic substitution reaction with common alkyl halides.

Isoindoline is used to make a chiral diamine catalyst from L-proline for the asymmetric acylation of alcohols.1

Isoindolinone and isoindoline pigments are high quality products. They are used in general and high grade industrial paints including original automobile and automotive refinishes, in plastics and for spin dyeing, and in high grade printing inks, especially for metal deco, laminated plastic sheets, and in printing inks for bank notes and securities.

The Journal of Organic Chemistry, 53, p. 5381, 1988 DOI: 10.1021/jo00257a041
Synthetic Communications, 18, p. 2055, 1988 DOI: 10.1080/00397918808068274