490-55-1

Name	amiphenazole
CAS	490-55-1
EINECS(EC#)	207-713-8
Molecular Formula	C9H9N3S
MDL Number	MFCD00128273
Molecular Weight	191.25
MOL File	490-55-1.mol

Synonyms

Daftazol Phenamizol Amifenazol Amiphenazol Amifenazole Phenamizole amiphenazole Amifenazol [inn-spanish] 5-phenylthiazole-2,4-diaMine 5-PHENYL-2,4-THIAZOLEDIAMINE 2,4-Diamino-5-phenylthiazole 6020-54-8 (Mono-hydrobromide) 942-31-4 (Mono-hydrochloride) 2,4-Thiazolediamine, 5-phenyl- 5-phenyl-1,3-thiazole-2,4-diamine

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Chemical Properties

Melting point	163.5°C (rough estimate)
Boiling point	413.3±25.0 °C(Predicted)
density	1.1906 (rough estimate)
refractive index	1.5300 (estimate)
pka	5.12±0.10(Predicted)

Hazard Information

Originator

Aamphisol,RJR

Definition

ChEBI: Amiphenazole is a member of thiazoles.

Manufacturing Process

Thiourea reacted with α-bromophenylacetonitrile and as a result of this reaction 2-(cyanophenylmethyl)isothiourea was obtained.
By cyclisation of the 2-(cyanophenylmethyl)isothiourea 2,4-diamino-5- phenylthiazole (amiphenazol) was produced.

Therapeutic Function

Respiratory stimulant, Barbiturate antagonist, Morphine antagonist

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 4517, 1951 DOI: 10.1021/ja01154a005

Purification Methods

The thiazole crystallises from aqueous EtOH or water. Store it in the dark under N2. The hydrochloride has m 273-274o(dec) (from MeOH/EtOAc), and the picrate has m 189-191o(dec) (from H2O). [Davies et al. J Chem Soc 3491 1950, Dodson & Turner J Am Chem Soc 73 4517 1951, Beilstein 27 III/IV 5139.]

Supplier

Wuhan TCASChem Technology Co., Ltd.

Telephone027-027-86697669 13986148687

Websitehttps://www.tcaschem.com

Candia Thamtech Company Limited

Telephone0371-86615086 18203638366 0371-86159066 13526786601

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15771/0.htm

Tianjing Geneston Bio-tech Co.,Ltd.

Telephone022-60131465 18920720807

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16827/0.htm

Hubei Jusheng Technology Co.,Ltd.

Telephone18871490254

Websitehttp://www.hubeijusheng.com

Cato Research Chemicals Inc.

Telephone 13342851930

Websitehttps://www.cato-chem.com/

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