479077-02-6

MMPIP Hydrochloride is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization.

Potent allosteric mGlu 7 -selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC 50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC 50 = 15 nM), indicating inverse agonist activity.

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