478926-45-3

Name	Benzenepropanoic acid, 3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]-α-(1-methylethoxy)-, (αS)-
CAS	478926-45-3
Molecular Formula	C22H23ClFNO5
Molecular Weight	435.88
MOL File	478926-45-3.mol

Synonyms

E3030 E-3030 E 3030 E-3030 free acid E 3030 free acid,E3030 free acid Benzenepropanoic acid, 3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]-α-(1-methylethoxy)-, (αS)- Benzenepropanoic acid, 3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]-α-(1-methylethoxy)-, (αS)-

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Chemical Properties

Boiling point	591.5±50.0 °C(Predicted)
density	1.29±0.1 g/cm3(Predicted)
pka	3.59±0.10(Predicted)

Hazard Information

Uses

E-3030 free acid is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, exhibiting significant antidiabetic and lipid-modulating effects. E-3030 decreases blood glucose, triglyceride, non-esterified fatty acids, and insulin levels, while increasing blood adiponectin levels. E-3030 improves glucose tolerance and shows remarkable triglyceride- and non-high-density lipoprotein cholesterol-lowering effects in animal models.

References

[1] Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs DOI:10.1254/jphs.fp0072346

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