474391-66-7

Isoprostanes are prostaglandin (PG)-like compounds produced in vivo by free radical-catalyzed peroxidation of arachidonoyl-containing lipids. 8-iso PGA₂ is one of several isoprostanes produced from peroxidation of arachidonic acid esterified in phospholipids. 8-iso PGA₂ is the dehydration product of 8-iso PGE₂, a potent renal vasoconstrictor. Evidence for the in vivo production of 8-iso PGA₂ has been shown in rat liver under conditions of oxidative stress. There are no published studies of the pharmacological properties of 8-iso PGA₂.

15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid[1][2][3].

ChEBI: 8-iso Prostaglandin A2 is a prostanoid.

[1] Chen Y, et al. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem. 1999 Apr 16;274(16):10863-8. DOI:10.1074/jbc.274.16.10863
[2] Musiek ES, et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem. 2006 Jun;97(5):1301-13. DOI:10.1111/j.1471-4159.2006.03797.x
[3] Benndorf RA, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis. Circ Res. 2008 Oct 24;103(9):1037-46. DOI:10.1161/CIRCRESAHA.108.184036