444807-47-0

557-21-1

154825-97-5

444807-47-0

Step C: Under argon protection, the intermediate (4.05 g), zinc cyanide (1.3 g) and tetrakis(triphenylphosphine)palladium (456 mg) obtained from step B were dissolved in dry and degassed N,N-dimethylformamide (30 mL), and the reaction was stirred at 80 °C overnight. After completion of the reaction, the mixture was concentrated, diluted with ethyl acetate, washed sequentially with 0.5 N hydrochloric acid and saturated brine, and the organic phase was dried over anhydrous sodium sulfate and purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, 9:1 to 4:1) to afford methyl 2-(4-cyanophenyl)-2-methylpropionate (3.05 g, 95% yield) as a colorless oil. Mass spectrometric detection showed [M+H]+ peak of 204.