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16-PA can be used as an anti-corrosive coating by forming a SAM on metal oxide surfaces for potential use in biomedical applications. It can also be deposited on indium oxide (ITO) substrates for the immobilization of surface atoms.

16-Phosphonohexadecanoic acid (16-PA) is an alkyl phosphonic acid that forms a self-assembled monolayer (SAM). It yields a close packed pattern with densely arranged alkyl groups. These SAMs are robust and stable in aqueous solutions over a wide pH range.