4424-20-8

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• Synthesis

  1,2-Phenylacetonitrile was dissolved in 150 mL of DMF, and 15.86 g (142 mmol) of potassium tert-butoxide was added at an internal temperature of -10 to 0 °C. The mixture was stirred at 0–5 °C for 2 h. Then, 200 mL of water and 22 mL of 30% hydrochloric acid were added at 0–5 °C, and the mixture was stirred for 1 h. The mixture was filtered to obtain a crude product, which was then dissolved in 170 mL of methanol and recrystallized. After filtration and drying, 20.87 g of 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE was obtained, with a yield of 89%.;

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