4303-70-2

White Solid

Structural analog of oleamide (cis-9,10-octadecenoamide), a sleep-inducing fatty acid amide found naturally in cerebrospinal fluid.

Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats. It inhibits rat microsomal epoxide hydrolase (mEH; K_i = 70 nM). Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A₂ (PLA₂). In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.

ChEBI: Elaidamide is a fatty amide.

Store at -20°C

[1] BENJAMIN F. CRAVATT. Chemical Characterization of a Family of Brain Lipids That Induce Sleep[J]. Science, 1995, 268 5216. DOI: 10.1126/science.7770779
[2] CHRISTOPHE MORISSEAU. Inhibition of Microsomal Epoxide Hydrolases by Ureas, Amides, and Amines[J]. Chemical Research in Toxicology, 2001, 14 4: 409-415. DOI: 10.1021/tx0001732
[3] MAHENDRA K. JAIN. Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2[J]. Journal of Medicinal Chemistry, 1992, 35 19: 3584-3586. DOI: 10.1021/jm00097a018