429676-93-7

Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G (IC₅₀ = 53 nM). It weakly inhibits or has no effect on related proteases, including chymotrypsin, thrombin, plasmin, trypsin, tryptase, and elastase.

Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G.

cathepsins G

[1] greco mn, hawkins mj, powell et, almond hr jr, corcoran tw, de garavilla l, kauffman ja, recacha r, chattopadhyay d, andrade-gordon p, maryanoff be. nonpeptide inhibitors of cathepsin g: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. j am chem soc. 2002;124(15):3810-1.