SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 μg/ml, 0.0113 μg/ml per mg/ml, 1.0 h and 0.224 μg.h/ml, respectively[1].SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with?P. yoelii.?SJ000025081 can result in a 90% suppression of the parasitemia[1].
| Animal Model: | 6 weeks old CD-1 mice[1] |
| Dosage: | 5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg |
| Administration: | Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days |
| Result: | Was active in a malaria murine model infected with P. yoelii. |
