Synthesis
General procedure for the synthesis of 1-(5-bromo-2-nitrophenyl)ethanone from 3'-bromoacetophenone: 100 g of 3'-bromoacetophenone was slowly added dropwise to 500 ml of a mixture of sulfuric acid and nitric acid (1:7, v/v), pre-cooled to -20°C, kept the reaction temperature at -20°C and stirred overnight. Upon completion of the reaction, the reaction mixture was quenched by pouring it into ice water, and the precipitate was collected by filtration to give 107 g of 2-nitro-5-bromoacetophenone, the product was a yellow solid in 87% yield.
References
[1] Patent: CN102898374, 2016, B. Location in patent: Paragraph 0027-0029
[2] Chemical Communications, 2015, vol. 52, # 2, p. 331 - 334
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 11, p. 2504 - 2518
[4] Journal of the American Chemical Society, 1996, vol. 118, # 34, p. 8127 - 8135
