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2,5-Diethyltetrahydrofuran can be used in analytical and biological studies for enhanced resolution of Mentha piperita volatile fraction using a novel medium-polarity ionic liquid gas chromatography stationary phase.

2,5-Diethyltetrahydrofuran finds use almost exclusively in the reconstruction of certain essential oils, used in flavor compositions, particularly members of the Mint family. Due to the very high vapor pressure (at room temperature) of this material, it will probably not find any use in perfume compositions, except as a component of certain artificial essential oils or bases, entering the perfume as minor base-components (“subcompounds”).