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1-(Difluoromethyl)-3-nitro-benzene is an intermediate for the preparation of N2-Phenylguanine derivatives as Inhibitors of Herpes Simplex Virus Thymidine Kinases, useful as a potential treatment for recurrent virus infections.

α,α-Difluoro-3-nitrotoluene, is an intermediate for the preparation of N2-Phenylguanine derivatives as Inhibitors of Herpes Simplex Virus Thymidine Kinases, useful as a potential treatment for recurrent virus infections.