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D-ribo-phytosphingosine (C17 base) has been used as a standard for the quantification of total plant long-chain bases (LCB) by gas chromatography-mass spectrometry (GC-MS).

D-ribo-phytosphingosine helps in maintaining the structural integrity of membrane. It also controls cellular growth and mediates the he at stress response of yeast. In additionPHS acts as a precursor for synthesis of various key lipid mediators including PHS 1-phosphateinositol phosphorylceramide and KRN7000 (α-anomer of galactosylceramide). This phospholipid also has an ability to stimulate keratinocyte differentiation. ThereforePHS is used as an active constituent in cosmetic formulations.