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Decanoylcarnitine is a decanoic acid ester of carnitine. Decanoylcarnitine bis a medium-chain acylcarnitine that may facilitate the transport of long-chain fatty acids into the mitochondria where fatty acids undergo β-oxidation. Decanoylcarnitine is used as an analytical reference standard using GC- or LC-MS methods.

Decanoylcarnitine serves as a specific diagnostic biomarker for metabolites found in medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, especially in neonates, glutaric acidemia type II, celiac disease, and adolescent obesity. Secondary marker of medium-chain ketoacyl-CoA thiolase deficiency.

The product is used primarily as a control for MS/MS.

Decanoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in the following:

• In dried blood spots using chip-based nanoelectrospray source coupled with high resolution mass spectrometry (chip-based nanoESI- HRMS) and targeted liquid chromatography-tandem mass spectrometry (LC/MS/MS).
• In biological samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC/MS/MS).

ChEBI: O-decanoyl-L-carnitine is an O-acyl-L-carnitine that is L-carnitine having decanoyl as the acyl substituent. It has a role as a human metabolite. It is an O-decanoylcarnitine and a saturated fatty acyl-L-carnitine.

Decanoyl-L-carnitine, belonging to the class of acylcarnitines, serves as a specific diagnostic metabolite biomarker, found in medium-chain acyl CoA dehydrogenase (MCAD) deficiency especially in newborns.

Decanoylcarnitine is useful in the diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency deficiencyoxidation disorders.