398515-96-3

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits A? production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor th at binds to γ-secretase at the substrate docking site. DAPTalso a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors th at affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteinsnicastrinAph-1 and Pen-2.

[1] Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. DOI:10.1074/jbc.C300019200