ChemicalBook CAS DataBase List 396091-76-2

396091-76-2

Name	Pasireotide Acetate
CAS	396091-76-2
Molecular Formula	C60H70N10O11
MDL Number	MFCD32666205
Molecular Weight	1107.28
MOL File	396091-76-2.mol

Chemical Properties

storage temp.	Store at -20°C, protect from light, stored under nitrogen
solubility	DMSO : 100 mg/mL (90.31 mM; Need ultrasonic)
form	Solid
color	White to off-white
Sequence	Cyclo[{4-(NH2-C2H4-NH-CO-O-)Pro}-Phg-{D-Trp}-Lys-{Tyr(4-Bzl)}-Phe]

Hazard Information

Uses

Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2][3].

in vivo

Pasireotide acetate (160 mg/kg/month; s.c. for 4 months) significantly decreases the serum insulin, increases serum glucose, reduces the tumor size and increases apoptosis in Pdx1-Cre^[2].
Pasireotide acetate (2-50 μg/kg; s.c. twice daily for 42 days) exerts the antinociceptive and antiinflammatory actions via the SSTR2 receptor in a mouse model of immune-mediated arthritis^[4].

Animal Model:	12 month-old conditional Men1 knockout mice with insulinoma^[2]
Dosage:	160 mg/kg/mouth
Administration:	S.c. every month for 4 months
Result:	Decreased the serum insulin from 1.060 μg/L to 0.3653 μg/L and increased the serum glucose from 4.246 mM to 7.122 mM. Significantly reduced the tumor size and increased apoptosis.

References

[1] Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44. DOI:10.1021/jm021093t
[2] Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77. DOI:10.1016/j.surg.2012.08.021
[3] Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62. DOI:10.1002/art.30410
[4] Schmid HA, et, al. Pasireotide (SOM230): development, mechanism of action and potential applications. Mol Cell Endocrinol. 2008 May 14;286(1-2):69-74. DOI:10.1016/j.mce.2007.09.006

Spectrum Detail

Supplier

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Chengdu Youngshe Chemical Co., Ltd.

Telephone+86-17380623303

Websitehttps://shop326109856.taobao.com/

Hangzhou Peptidego Biotech Co.,Ltd.

Telephone0571-87213919 15967184799

Websitehttp://peptidego.com

Shanghai Luofa Biochemical Technology Co., Ltd.

Telephone021-51111890 15317326293

Websitehttps://www.molnova.cn/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Telephone0571-87213919 17306812703

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1355681/0_EN.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Telephone4000862158 18117107507

Websitehttps://www.med-life.cn/

Jiangsu Chunhui Medical Technology Co., Ltd

Telephone 13913819195

Website

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

Shanghai Fengyong Biotechnology Co., Ltd.

Telephone021-10000000 13000000000

Websitehttps://www.abmole.cn

Guangzhou Ruidi Biotechnology Co., Ltd.

Telephone020-82099279 18988941402

Websitehttp://www.ubiochem.com/

Chengdu Youngshe Chemical Co., Ltd.

Telephone +86-18108235634

Websitehttp://www.youngshechem.com/

1of3

Related Products

Send Inquriy