39196-18-4

Thiofanox is a colorless solid with a pungent odor.

THIOFANOX is a colorless solid with a pungent odor. Used as a systemic insecticide and acaricide.

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.

THIOFANOX is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

THIOFANOX is a carbamate pesticide. Carbamate pesticides are moderately to highly toxic. It is a cholinesterase inhibitor.

(Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire. When heated to decomposition, THIOFANOX emits very toxic fumes of nitrogen and sulfur oxides. Stable at normal storage temperature; reasonably stable to hydrolysis at less than 86F at pH 5-9.

A potential danger to those involved in the manufacture, formulation and application of this thiocarbamate systemic insecticide and acaricide.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24-48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

UN2757 Carbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Thiocarbamate esters are combustible. They react violently with powerful oxidizers such as calcium hypochlorite. Poisonous gases are generated by the thermal decomposition of thiocarbamate compounds, including carbon disulfide, oxides of sulfur, oxides of nitrogen, hydrogen sulfide, ammonia, and methylamine. Many materials in this group slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Flammable gases are generated by the combination of

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Thiofanox is a systemic soil insecticide used for the control of aphids, mites, thrips, plant bugs, leafhoppers and beetles in/on sugar beet and potatoes.

The commercial production of thiofanox involves the synthesis of a systemic oxime carbamate compound through a series of chemical reactions that incorporate key functional groups such as a tert-butyl moiety, a methylsulfanyl side chain, and a carbamate linkage. The process begins with the preparation of intermediates like S-methyl-substituted alkylamines, which are then reacted with carbamoylating agents to form the final active ingredient.

Systemic. Acetylcholinesterase (AChE) inhibitor.

The insecticidal carbamates are cholinergic. Poisoned insects and animals exhibit violent convulsions and other neuromuscular disturbances. These insecticides carbamylate acetylcholinesterase and may have a direct action on acetylcholine receptors. The mechanism of interaction with acetylcholinesterase is analogous to the normal three-step hydrolysis of acetylcholine. However, the third reaction step is much slower for the carbamylated enzyme than for the acetylated one. The importance of structural complementarity of the insecticidal carbamates to the active site of acetylcholinesterase is demonstrated by the pronounced difference in activities of D-2-(sec-butylphenyl) methylcarbamate and L-2-(sec-butylphenyl) methylcarbamate (the L isomer is five times more toxic) and of the 2-, 3-, and 4-substituted phenylmethylcarbamates, where the 4-isomers are virtually inactive.
Detoxification of carbamate insecticides occurs in vivo through microsomal hydroxylation, N-demethylation of carbamyl nitrogen, side chain oxidation, and ring hydroxylation. Methylenedioxyphenyl synergists prevent oxidation

The hydrolytic degradation and metabolism of thiofanox in soils, plants and animals follow a common pathway. Oxidation of the S-methyl moiety is the primary reaction to yield the thiofanox sulfoxide and sulfone. Hydrolysis of the carbamate linkage to yield the oximes is only a minor pathway for thiofanox and its oxidation products (Scheme 1).

Thiofanox (1) is stable to hydrolysis at acidic and neutral pH levels, but readily degrades in alkaline solution (>pH 10). The major products resulted from the oxidation of the S-methyl moiety to yield thiofanox sulfoxide (2) and thiofanox sulfone (3). Hydrolysis of thiofanox and its oxidation products to the corresponding oximes (4, 5 and 6), and the further oxidation of thiofanox sulfone oxime (6) to the ketone (7) were minor reactions (Chin et al., 1976).

Insecticide; Acaricide