39036-04-9

L-α-Diheptanoyllecithin is used in novel therapies for treating and preventing chronic rhinosinusitis by disrupting preformed bacterial biofilm using antibiotics in combination with phospholipids.

ChEBI: 1,2-diheptanoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 14:0 in which both acyl groups are specified as heptanoyl. It has a role as a detergent. It is functionally related to a heptanoic acid.

DHPC preserves the native conformation and therefore the activity of the solubilized proteins. The three dimensional structure and activity of proteins are retained not only at the 10-15mM DHPC concentrations at which maximum solubilization usually occursbut also over a large range of DHPC concentrations (up to 40mM). Not only is the three dimensional structure and hence the activity of most protein retained in excess DHPCbut the proteins also appear to be stable in DHPC. Such a result suggests th at the direct interaction of DHPC with integral membrane proteins is weak. If the interaction of DHPC with membrane proteins is indeed weakit follows th at intrinsic membrane lipids will remain associated with the membrane proteins. Solubilization Mechanism DHPC is thought to exert a wedge-like effect on the neighboring lipidsmainly due to its bulky polar group and short hydrocarbon chains. This produces membrane destabilization at relatively low DHPC concentrations. All membranes inv