AJH-836 is an activator of Munc13-1 and PKC ε/α (Kd: 4.5 nM for PKCα) . AJH-836 triggers the translocation of Munc13-1 from the cytoplasm to the plasma membrane. AJH-836 can be used for research of neurodegenerative diseases[1].
References
[1] Das J, Yet al. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 Aug 31. DOI:10.1021/acs.biochem.3c00375
