3854-04-4

Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M₂, M₃, and M₂/M₃ knockout mice (EC₅₀s = 0.36, 0.52, 1.62, and 1.48 μM, respectively). It also increases M₄-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC₅₀ = 0.14 μM). Oxotremorine M inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M₁ receptors and KCNQ2/3 potassium channels (IC₅₀ = 1.1 μM). It also directly inhibits KCNQ2/3 potassium channels, decreasing KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner.

Oxotremorine M is a muscarinic receptor agonist.

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