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Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.

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A major metabolite of Abacavir

Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3).

ChEBI: Abacavir 5'-carboxylic acid is a monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189). It has a role as a metabolite. It is functionally related to an abacavir.

[1] MICHAEL A MARTIN  Deanna L K. Abacavir pharmacogenetics–from initial reports to standard of care.[J]. Pharmacotherapy, 2013, 33 7: 765-775. DOI: 10.1002/phar.1278
[2] CATARINA CHARNEIRA. Reactive Aldehyde Metabolites from the Anti-HIV Drug Abacavir: Amino Acid Adducts as Possible Factors in Abacavir Toxicity[J]. Chemical Research in Toxicology, 2011, 24 12: 2129-2141. DOI: 10.1021/tx200337b