3819-88-3

394-01-4

3819-88-3

In a Schlenk reaction tube equipped with a magnetic stirrer, 6.7 mg of palladium trifluoroacetate (Pd(TFA)2), 28.6 mg of cuprous oxide (Cu2O), 6.4 mg of potassium phosphate (K3PO4), 37 mg of 4-fluoro-2-nitrobenzoic acid, 36 mg of sodium iodide (NaI) and 194 mg of bismuth ammonium nitrate hydrate (Bi(NO3)3- 5H2O). The reaction mixture was heated to 170 °C under oxygen atmosphere with continuous stirring for 20 hours. Upon completion of the reaction, the reaction was quenched by the addition of an appropriate amount of distilled water, followed by extraction with ethyl acetate (10 mL each time) three times and combining the organic phases. The combined organic phases were concentrated to give 29.4 mg of 1-fluoro-3-iodo-5-nitrobenzene in 55% yield.