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Holothurin A is a potent inhibitor against BCL2, HDAC1 and PTPN2 with an anticancer activity, which is derived from sea cucumber Holothuria scabra. Holothurin A plays an essential role in the process of apoptosis, cell cycle and suppressing tumor[1].

[1] Wargasetia T L, et al. Anticancer potential of holothurin A, holothurin B, and holothurin B3 from the sea cucumber Holothuria scabra[C]//AIP Conference Proceedings. AIP Publishing, 2020, 2231(1).