37589-80-3

Name	GTP-GAMMA-S SODIUM SALT
CAS	37589-80-3
Molecular Formula	C10H12N5Na4O13P3S
MDL Number	MFCD03791271
Molecular Weight	627.17
MOL File	37589-80-3.mol

Synonyms

GTP-γ-S GTP-GAMMA-S GTP-GAMMA-S, NA GTP-GAMMA-S SODIUM SALT guanosine5’-o-(3-thiotriphosphate Guanosine 5'-γ-thiotriphosphoric acid Guanosine 5'-(γ-thiotriphosphoric acid) Guanosine 5'-O-(γ-thiotriphosphoric acid) 5'-Guanylyloxyphosphonyloxythiophosphonic acid GUANOSINE-5'-O-(3-THIOTRIPHOSPHATE) SODIUM SALT GUANOSINE-5'-O-(3-THIOTRIPHOSPHORIC ACID), SODIUM GUANOSINE-5'-(GAMMA-THIO)-TRIPHOSPHATE, SODIUM SALT GUANOSINE-5'-[GAMMA-THIO]TRIPHOSPHATE TETRASODIUM SALT guanosine-5’-o-(3-thiotriphosphate),(gtp-g-s),sodiumsalt Guanosine-5′-[γ-thio]triphosphate tetrasodium salt solution Guanosine-5μ-[γ-thio]triphosphate solution tetrasodium salt Guanosine5'-(trihydrogen diphosphate), P'-anhydride with phosphorothioic acid

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Chemical Properties

density	2.68±0.1 g/cm3(Predicted)
storage temp.	-20°C (-15°C to -25°C)
form	solution (deep frozen)
pka	0.67±0.50(Predicted)

Safety Data

WGK Germany	-
F	10-21

Hazard Information

Uses

GTP-γ-S has been used:

in G-Protein activation assay to assess the functionality of protease-activated receptor 4 (PAR4)
in fluorimetric guanine nucleotide exchange assay of G protein alpha subunits (Gα)
to monitor the Rac family small guanosine triphosphatase (GTPase) 2 (Rac2)-stimulated activity of phospholipase Cγ2 mutants

Definition

ChEBI: Guanosine 5'-[gamma-thio]triphosphate is a nucleoside triphosphate analogue. It is functionally related to a GTP.

General Description

Guanosine 5′-O-(3-thiotriphosphate), tetralithium salt (GTP-γ-S) is a non-hydrolysable analog of GTP. It is an inhibitor of phosphodiesterase in photoreceptors.

Biochem/physiol Actions

Guanosine 5′-O-(3-thiotriphosphate) (GTP-γ-S) activates guanine-nucleotide-binding proteins and is slowly hydrolyzed enzymatically. It inhibits guanosine triphosphatase (GTPases) more potently than guanosine triphosphate (GTP),

Supplier

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Chizhou Kailong Import and Export Trade Co., Ltd.

Telephone

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16778/0.htm

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai Universal Biotech Co.,Ltd

Telephone 18768175414

Websitehttps://www.univ-bio.com/

Hubei Aiputi Bioengineering Co., Ltd.

Telephone 17762444226

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList546373/0.htm

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