37293-17-7

Name	bleomycin A6
CAS	37293-17-7
Molecular Formula	C60H96N20O21S2
MDL Number	MFCD01751489
Molecular Weight	1497.67
MOL File	37293-17-7.mol

Synonyms

Boanmycin bleomycin A6 Pingyangmycin A6 Zhengguangmycin A6 N1-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]bleomycinamide Bleomycinamide, N1-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-

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Chemical Properties

density	1.53±0.1 g/cm3(Predicted)
pka	10.84±0.46(Predicted)

Safety Data

Toxicity

LD50 intramuscular in mouse: 70530ug/kg

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Hazard Information

Uses

Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3].

in vivo

Boanmycin (BAM) (i.p., 10 or 15 mg/kg, twice a week, 5 weeks) can effectively inhibit the growth of tumors in BALB/c nude mice with HT-29, Hce-8693 or CT-26 cells^[1].

Animal Model:	BALB/c nude mice with HT-29 or Hce-8693 cells^[1]
Dosage:	10 or 15 mg/kg
Administration:	Intraperitoneal injection; twice a week; 5 weeks
Result:	Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model.

Animal Model:	BALB/c nude mice with CT-26 cells^[1]
Dosage:	10 mg/kg
Administration:	Intramuscular injection; every second day; 10 times
Result:	Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%.

References

[1] Y C Deng, et al. Activity of boanmycin against colorectal cancer. World J Gastroenterol. 2001 Feb;7(1):93-7. DOI:10.3748/wjg.v7.i1.93
[2] Hao Tang, et al. Effect of boanmycin on apoptosis and cell cycle of human esophageal cancer(Eca-109) cells]. Ai Zheng. 2002 Aug;21(8):855-9. PMID:12478892
[3] Peng Chen, et al. The chemotherapeutic drug boanmycin induces cell senescence and senescence-associated secretory phenotype factors, thus acquiring the potential to remodel the tumor microenvironment. Anticancer Drugs. 2016 Feb;27(2):84-8. DOI:10.1097/CAD.0000000000000304

Supplier

Shanghai Boyle Chemical Co., Ltd.

Telephone 021-50182298 021-50180596

Websitehttp://www.boylechem.com

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,

Telephone18915873328 18915873328

Websitehttps://www.xianglongpharm.com/

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