37087-94-8

Name	tibric acid
CAS	37087-94-8
EINECS(EC#)	253-344-0
Molecular Formula	C14H18ClNO4S
MDL Number	MFCD00865752
Molecular Weight	331.818
MOL File	37087-94-8.mol

Synonyms

Tibric CP-18524 tibric acid 2-Chloro-5-[(3α,5α-dimethylpiperidino)sulfonyl]benzoic acid 2-Chloro-5-[[(3R,5S)-3,5-dimethylpiperidino]sulfonyl]benzoic acid 2-Chloro-5-[[(3S,5R)-3,5-dimethylpiperidino]sulfonyl]benzoic acid

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Chemical Properties

form	Solid
color	White to off-white

Hazard Information

Uses

Tibric acid (CP 18524) has similar effects to those of hypolipidemic agents. Tibric acid has orally active triglyceride-lowering effects. Tibric acid can be used for research of hypertriglyceridemia[1][2].

in vivo

Tibric acid (13-125 mg/kg/d, oral administration, daily for 1 week) reduces serum cholesterol and triglyceride levels in rats^[2].

Animal Model:	Rats^[1]
Dosage:	13, 25, 125 mg/kg/d
Administration:	oral administration, daily for 1 week
Result:	Decreased serum cholesterol and triglyceride levels, but increased total liver content of cholesterol, phospholipids, and triglycerides.

References

[1] Bielmann P, et al. Dose-response to tibric acid: a new hypolipidemic drug in type IV hyperlipoproteinemia. Clin Pharmacol Ther. 1975 May;17(5):606-11. DOI:10.1002/cpt1975175606
[2] Cayen MN, et al. Effect of tibric acid on hepatic cholesterol synthesis in rats. Lipids. 1977 Aug;12(8):684-8. DOI:10.1007/BF02533766

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Websitehttps://www.targetmol.cn/

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Websitewww.dycnchem.com

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