Chemical Properties
Off-White Solid
Originator
Pholedrine Sulfate, ZYF Pharm Chemical
Definition
ChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process
100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic Function
Sympathomimetic, Mydriatic, Analeptic, Vasopressor
