36840-10-5

LPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM)[1].

LPA2 antagonist 2 is a selective LPA2 antagonist with IC50 of 28.3 nM and Ki of 21.1 nM, >480-fold selectivity over LPA3 (IC50 of 13.85 μM).

Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation.

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[1] Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17. DOI:10.1016/j.bmc.2008.04.035