3541-42-2

2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].

ChEBI: (E)-3-(2-Hydroxyphenyl)-2-propenal is a member of cinnamaldehydes.

Synthetic Communications, 34, p. 1223, 2004 DOI: 10.1081/SCC-120030309

To a solution of 2-hydroxybenzaldehyde (10 g, 81.8 mmol) in THF (150 ml) was added (formylmethylene)triphenylphosphine (24.89 g, 81.8 mmol) at room temperature. The resulting reaction mixture was refluxed at 100 °C for 20 hours. The reaction mixture was c

[1] Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84. DOI:10.1021/np400216m
[2] Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55. DOI:10.1016/j.canlet.2018.07.015
[3] Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884. DOI:10.1038/s12276-021-00620-z