Description
AHR-activator-1023 is an activator of the aryl hydrocarbon receptor (AHR).It is also a specific modulator of FGF2-induced branching morphogenesis.
Uses
AHR activator 1 is an aryl hydrocarbon receptor activator with activity regulating fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. AHR activator 1 prevents the formation of cellular branches by inhibiting AHR signaling. AHR activator 1 also associates with adhesion of dissociated linkers, suggesting the importance of dissociated linkers in the inhibition of branching by AHR agonists. Studies of AHR activator 1 reveal its functional role in mammary gland morphogenesis and play a role in inhibiting FGF-induced invasion[1].
References
[1] Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis
