35121-78-9

Prostacyclin,ZYF Pharm Chemical

Inhibitor (platelet). [Names previously used: Prostacyclin, PGI2, Prostagland in I2, Prostaglandin X, PGX].

ChEBI: Prostaglandin I2 is a prostaglandins I. It has a role as a mouse metabolite. It is a conjugate acid of a prostaglandin I2(1-).

Preparation of prostacyclin:
Pig aortas were stripped of adventitia, snap frozen in liquid nitrogen, crushed into a fine powder, resuspended in 0.05 M Tris buffer (pH 7.5) (1:4, w:v) andhomogenised at high speed in a Polytron (KIMENATIC, LUCERNE, SWITZERLAND) homogenizer. The homogenate was centrifuged for 15 min and the resulting supernatant centrifuged again for 5 min. The pellet was discarded, while the pellet obtained after centrifugation of the supernatant was resuspended in deionized water and lyophilized. An average yield of 150 mg of aortic microsomal powder (51% protein) per 100 g of aortic tissue was obtained.

Flolan (GlaxoSmithKline).

Platelet aggregation inhibitor, Antimetastatic