34595-33-0

General procedure for the synthesis of 5-amino-2-(piperidin-1-yl)benzonitrile from 5-nitro-2-piperidinobenzonitrile: 5-nitro-2-(piperidin-1-yl)benzonitrile was dissolved in an appropriate amount of solvent, and the reduction reaction was carried out by the addition of NaBH4 for 30 min. Upon completion of the reaction, 2.0 g of yellow solid (compound 11) was added for subsequent processing.

[1] Patent: CN106892871, 2017, A. Location in patent: Paragraph 0135; 0138; 0139
[2] Patent: US2006/79696, 2006, A1. Location in patent: Page/Page column 38
[3] Patent: EP1176140, 2002, A1. Location in patent: Page 54