Uses
Endo CNTinh-03 is inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). Endo CNTinh-03 inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model[1].
Biological Activity
Cyclic nucleotide suppressor.
CNTinh-03 is a small-molecule general suppressors of cellular cyclic nucleotides. It reduces basal and agonist-induced elevation of cytoplasmic cAMP and cGMP in multiple cells and in response to different types of agonists. The mechanism of action involves nonselective activation of phosphodiesterase (PDE).
