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2-Ethoxypyridine 1-Oxide is used for acyl activating agent for peptide synthesis;^[1] catalyst for phosphotriester bond formation.^[2]

2-Ethoxypyridine 1-Oxide is prepared from 2-ethoxypyridine and Hydrogen Peroxide^[3] or 2-chloropyridine 1-oxide and ethanolic Sodium Ethoxide.^[4]

1. Paquette, L. A. JACS 1965, 87, 5186.
2. Efimov, V. A.; Chakhmakhcheva, O. G.; Ovchinnikov, Y. A. Nucleic Acids Res. 1985, 13, 3651.
3. Newbold, G. T.; Spring, F. S. JCS 1948, 1864.
4. Gardner, J. N.; Katritzky, A. R. JCS 1957, 4375.