343263-95-6

DH 97 is an antagonist of melatonin receptor 2 (MT₂; K_is = 252 and 1,100 for human MT₂ and MT₁ receptors, respectively).

DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively[1].

ChEBI: N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]pentanamide is a member of indoles.

A relatively potent MT 2 melatonin receptor antagonist (pK i value = 8.03), displaying 89- and 229-fold selectivity over MT 1 and GPR50 (melatonin-related orphan receptor) respectively.

MT2: 252 nM (Ki); MT1: 1100 nM (Ki)

[1] O Nosjean, et al. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2. Biochem Pharmacol. 2001 Jun 1;61(11):1369-79. DOI:10.1016/s0006-2952(01)00615-3